The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to govern anti-tumor immunity

Pcif1 KO mice can significantly inhibit tumor growth. We attempted to explore the changes in tumor immune microenvironment of tumor-bearing mice after Pcif1 KO by single-cell sequencing. The tumors of the LLC subcutaneous tumor model of Pcif1 KO and WT mice were ground into single-cell suspension, and single-cell sequencing was performed