PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane

At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2) and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P).<br><br>The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008), MTMR2 (Cao et al. 2008), and MTMR4 (Lorenzo et al. 2006).

在早期内体膜中，肌管蛋白（MTM1）、肌管蛋白相关蛋白2（MTMR2）以及肌管蛋白相关蛋白4（MTMR4）通过去磷酸化磷脂酰肌醇3,5-二磷酸（PI(3,5)P2）将其转化为磷脂酰肌醇5磷酸（PI5P）。以下列出了上述蛋白及其相应的文献引用：MTM1（Cao et al. 2007, Cao et al. 2008）、MTMR2（Cao et al. 2008）和MTMR4（Lorenzo et al. 2006）。