Gene expression profile of calcium oxalate nephrocalcinosis in wild type and NLPR3 knock out mice.

Microarray analysis was used to assess the expression levels of mRNAs in kidney tissues of calcium oxalate (CaOx) nephrocalcinosis mouse model and normal mouse kidney tissues.The animals used in the experiment were male 6-8 weeks old wild type and NLPR3 knock out C57BL/6J mice. To establish a CaOx nephrocalcinosis mouse model, each mouse was intraperitoneally injected with saline or glyoxylate acid (Gly) (75 mg/kg/d, 200 μl) from day 1 to day 7. Animals were euthanized after 7 days, and kidney samples were collected at the time of euthanasia. MRNA expression profile in kidney tissues of of calcium oxalate (CaOx) nephrocalcinosis in wild type and NLPR3 knock out mice.