Early weaning induces programmed obesity in rats at adulthood through impairing fatty acid β-oxidation and cholesterol metabolism, which can be mitigated by leucine supplementation

To examined the underlying variation between early-weaned rats and normal rats, we identified differentially expressed genes using RNA-seq. Wistar rats (Age 23: CON, control group; EW, early weaned group. Age 63: CH, control group; EH, early weaned group) SD rats (Age 211: Con, control group; Ew, early weaned group; EW_Leu, early weaned group with 1.5% leucine in drinking water.)