Tumor Cell Heterogeneity and Dormancy in Single Disseminated Prostate Cancer Cells
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Tumor Cell Heterogeneity and Dormancy in Single Disseminated Prostate Cancer Cells
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2014-09-16
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The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer [scRNA-seq]. The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer [scRNA-seq]
Cancer cells often adapt a stem-like state resulting in lineage plasticity and phenotypic heterogeneity. We assessed the dynamics of lineage determination and cellular subpopulation expansion in treat
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Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states
Methods: To characterize the prostate cancer tumor microenvironment, we performed single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organoids from localized
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Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states
Methods: To characterize the prostate cancer tumor microenvironment, we performed single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organoids from localized
NIAID Data Ecosystem20
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer. Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer
Neuroendocrine prostate cancer (NEPC) is a subset of castration-resistant prostate cancer (CRPC) and is thought to derive from prostate adenocarcinoma. However, the cellular basis responsible for Neur
NIAID Data Ecosystem30
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states. Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states
Methods: To characterize the prostate cancer tumor microenvironment, we performed single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organoids from localized
NIAID Data Ecosystem20
