Single-cell RNA sequencing shows the heterogeneity of cancer-associated fibroblast in HBV-related hepatocellular carcinoma
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE202642
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We identified 5 distinct fibroblast subsets by sequencing 74957 single cells derived from 7 HBV-related HCC tissues, of which the CD36+ CAFs were highlighted, with enriched lipid metabolism and secreting high levels of macrophage migration inhibitory factor (MIF). CD36+ CAFs had tight interactions with CD33+ MDSCs through MIF/CD74 axis. We performed scRNA-seq derived from 7 HBV-related HCC tissues and 4 adjacent liver tissues
创建时间:
2025-05-07



