Asymmetric Domino Multicatalysis for the Synthesis of 3‑Substituted Phthalides: Cinchonine/NHC Cooperative System
收藏NIAID Data Ecosystem2026-03-08 收录
下载链接：
https://figshare.com/articles/dataset/Asymmetric_Domino_Multicatalysis_for_the_Synthesis_of_3_Substituted_Phthalides_Cinchonine_NHC_Cooperative_System/2325517
下载链接
链接失效反馈官方服务：
资源简介：
It
is demonstrated that two organocatalysts, achiral NHC and chiral
bifunctional cinchonine, are mutually compatible and operating concurrently
and effectively to promote the asymmetric domino oxidation/oxa-Michael
addition reaction. This protocol allowed access to both enantiomers
of a product by using two natural, inexpensive pseudoenantiomeric
cinchona alkaloids, cinchonine and cinchonidine, as well as to phthalides
containing a chiral quaternary carbon center in good enantioselectivities.
创建时间：
2016-02-18
