Gut microbiome in biliary atreisa

Biliary atresia causes neonatal cholestasis and rapidly progresses to cirrhosis if left untreated. Kasai portoenterostomy may delay cirrhosis. Biliary atresia remains among the most common indications for liver transplantation (LT) during childhood. Liver function and gut microbiome are interconnected. Disturbed liver function and enterohepatic signaling influences microbial diversity. We herein investigate the impact of LT and reestablishment of bile flow on gut microbiome-bile acid homeostasis in children with biliary atresia before, 3 months, 12 months and more than 24 months after LT.