Effects of allergen and airway constriction on gene expression in mouse lung

Airway hyperresponsiveness is found to be a heritable trait and the parents of respiratory patients often have this trait. To understand if airway constriction affects the lung and contributes to lung disease, we investigated the lungs that often occur airway constriction and compared those lungs with healthy lung and the lung with inflammation. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different tracheal tissues of BABL/c mouse at two time points.