The RFX transcription factor gene, daf-19, has dual funcitons in ciliated and non-ciliated neurons

Cilia are required for many sensory and motility related functions and are involved in growing number of genetic disorders termed ciliopathies. DAF-19, RFX type transcription factor controls expression of many cilia structure and function related genes. To this end, transcriptional profiling of daf-19 mutants (which do not form cilia) and wild-type animals was performed using selectively staged larval stages where cilia mature and maintained, structurally as well as functionally. We used microarray based expression analysis to detail expression control exerted by DAF-19 at various stages of life cycle