Association between the quantified brain and kidney pathology.

The statistical association between the quantified brain pathology (erythrocyte aggregations, microbleeds, microthromboses) and the quantified kidney pathology (erythrocyte aggregations, tubular protein cylinders, glomerulosclerosis) in SHRSP is demonstrated. Note the significant association between almost all cerebral and renal histopathological phenomena by using the Mann-Whitney-U test/ROC-analysis. After correction for age (logistic regression analysis/ROC-analysis) a significant association only remained between the occurrence of cerebral microbleeds and erythrocyte aggregations in the renal medulla as well as between the occurrence of cerebral mircothromboses and protein cylinders in the kidney cortex. AUC = the area under the curve.