肝癌发生发展过程中具有重要作用的Hippo 通路相关蛋白机器及其对肝癌干细胞的调控

肝癌干细胞是肝癌的发生发展和复发耐药的重要根源之一，Hippo信号通路的激活在维持肝癌干细胞的自我更新与肿瘤起始中发挥重要作用。本课题组首先发现Hippo通路的新调控基因，阐述其分子机制。本项研究阐述了SHANK2作为一个新的HIPPO通路调控因子，在肿瘤中高频扩增，并促进肝癌发生发展的分子机制。该数据集中包含相关研究的动物实验、蛋白印记等原始图片数据、癌症数据库汇总分析结果。同时，本课题组进行肝癌干细胞的高通量测序数据，对参与Hippo通路活化相关分子进行蛋白质谱检测，为肝癌干细胞的调控机制提供新的理论基础，为肝癌的诊疗提供新靶标和策略。

Hepatocellular carcinoma (HCC) stem cells (CSCs) are one of the critical origins of HCC initiation, progression, recurrence and drug resistance. Activation of the Hippo signaling pathway plays a crucial role in maintaining the self-renewal and tumor-initiating capacity of HCC CSCs. Our research team first identified a novel regulatory gene of the Hippo pathway and elucidated its molecular mechanism. This study elaborates the molecular mechanism by which SHANK2, a newly identified Hippo pathway regulator, is frequently amplified in tumors and promotes HCC initiation and progression. This dataset includes raw image data from related experiments such as animal assays and western blots, as well as aggregated analysis results from cancer databases. Additionally, our team generated high-throughput sequencing data for HCC CSCs and performed mass spectrometry detection of molecules involved in Hippo pathway activation, which provides a novel theoretical basis for the regulatory mechanism of HCC CSCs and new therapeutic targets and strategies for HCC diagnosis and treatment.

搜集汇总

背景与挑战

背景概述

该数据集聚焦于Hippo信号通路在肝癌干细胞调控中的作用，包含SHANK2作为新调控因子的发现及相关分子机制研究。数据涵盖动物实验、蛋白印记原始图片、癌症数据库分析、高通量测序和蛋白质谱检测结果，为肝癌诊疗提供新靶标和策略。数据集总大小为346.2MB，包含126个文件，属于临床医学肿瘤学领域。