In-situ cell-type specific chromatin topologies in the brain revealed by genome architecture mapping [ATAC-seq]

We report the application of genome architecture mapping in specific cell types in mouse brain. We generated cell-type specific chromatin contact maps in mouse dopaminergic neurons from the midbrain ventral tegmental area (VTA DN), pyramidal glutamatergic neurons from the cornus ammonis 1 region of the hippocampus (CA1 PGN), and non-neuronal post-mitotic oligodendrocytes from the somatosensory cortex (SSC_Olig). We explored cell-type specific chromatin topologies genome-wide at multiple genomic scales. Our data demonstrates that chromatin organization is cell type specific and reflects cell specialization at all genomic scales. bulk mESC ATAC-seq; VTA snATAC-seq Please note that the 'ATACseq_VTA*_DN' processed data was generated from both replicates and is linked to the ATACseq_VTA1_DN sample records.