Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655

Protein Data Bank Japan2024-12-11 更新2026-04-19 收录

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Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655 Descriptor: ALK tyrosine kinase receptor, NVL-655 Authors: Mente, S, Horan, J.C. Deposit date: 2024-07-31 Release date: 2024-09-18 Last modified: 2024-12-11 Method: X-RAY DIFFRACTION (1.58 Å) Cite: NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. Cancer Discov, 14, 2024

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2024-07-31