Copper-Catalyzed Regioselective Remote C–H Bond Chalcogenation of Aromatic Amine Derivatives without Using Any Large Template

A mild and convenient strategy has been developed for
the para-selective chalcogenation of anilide scaffolds
via C–H
bond functionalization. This methodology employs one of the most earth-abundant
and inexpensive Cu(II) catalysts and a commercially available simple
aryl chalcogen source without any complex directing template, exogenous
ligand, acid/base, oxidant, or other additives. The key feature of
this methodology is an impressive regioselectivity along with a wide
range of functional group tolerance with good to excellent yields
under aerobic conditions.