Aslanidi2009_caninePVJ

This a model from the article:
Optimal velocity and safety of discontinuous conduction through the
heterogeneous Purkinje-ventricular junction.

Aslanidi OV, Stewart P, Boyett MR, Zhang H. Biophys J
2009 Jul 8;97(1):20-39 19580741
,
Abstract:

Slow and discontinuous wave conduction through nonuniform junctions in cardiac
tissues is generally considered unsafe and proarrythmogenic. However, the
relationships between tissue structure, wave conduction velocity, and safety at
such junctions are unknown. We have developed a structurally and
electrophysiologically detailed model of the canine Purkinje-ventricular
junction (PVJ) and varied its heterogeneity parameters to determine such
relationships. We show that neither very fast nor very slow conduction is safe,
and there exists an optimal velocity that provides the maximum safety factor for
conduction through the junction. The resultant conduction time delay across the
PVJ is a natural consequence of the electrophysiological and morphological
differences between the Purkinje fiber and ventricular tissue. The delay allows
the PVJ to accumulate and pass sufficient charge to excite the adjacent
ventricular tissue, but is not long enough for the source-to-load mismatch at
the junction to be enhanced over time. The observed relationships between the
conduction velocity and safety factor can provide new insights into optimal
conditions for wave propagation through nonuniform junctions between various
cardiac tissues.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Aslanidi OV, Stewart P, Boyett MR, Zhang H. (2009) - version=1.0

The original CellML model was created by:
Catherine Lloyd

[e-mail]
The University of Auckland
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