GDP-bound KRAS G12D in complex with MCB-294
收藏Protein Data Bank Japan2025-10-29 更新2026-04-19 收录
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GDP-bound KRAS G12D in complex with MCB-294 Descriptor: (3~{R})-1-[2-[[(8~{S})-6-[bis(fluoranyl)methylidene]-2,3,5,7-tetrahydro-1~{H}-pyrrolizin-8-yl]methoxy]-7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-pyrido[4,3-d]pyrimidin-4-yl]-3-methyl-piperidin-3-ol, DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Li, K.K, Guo, R.-T. Deposit date: 2025-03-21 Release date: 2025-07-30 Last modified: 2025-10-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers. Cancer Cell, 43, 2025
创建时间：
2025-03-21
