Endometrial epithelial Arid1a is essential in early pregnancy

Endometrial epithelial Arid1a is necessary for normal gene expression and maintenance of a receptive endometrium at pre-implantation stage in mice. We used RNA-sequencing to determine the differences in uterine gene expression resulting from deletion of endometrial epithelial Arid1a. Uteri of adult Arid1a f/f and Ltf iCre/+ Arid1a f/f mice were collected at gestation day 3.5 for RNA extraction and sequencing.