Ulcerative Colitis but not DSS induced colitis associated microbiota promotes early colitis biomarkers in IL-10 -/- mice

The goal of the study was to determine if mice genetically susceptible to colitis are colonized with colitic-associated bacteria, will they exhibit an early onset and increased disease severity of colitis. The results of the study provide evidence for the use of fecal microbial transplantations from individuals with colitis to model the progression and severity of colitis in IL-10 -/- mice. Furthermore, the results of the study indicate that microbial stability is influential in disease progression.

本研究的目的是探究对结肠炎具有遗传易感性的小鼠是否被结肠炎相关细菌所感染，并表现出结肠炎的早期发病和疾病严重程度的增加。研究结果表明，从患有结肠炎的个体中提取的粪便微生物移植可用于模拟 IL-10-/- 小鼠结肠炎的进展和严重程度。此外，研究结果还表明，微生物的稳定性对疾病进展具有显著影响。