Data underlying the publication: YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico

Data belonging to the article "YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico"It contains the MATLAB code used to run all simulations, the fitting algorithms and the code used to obtain all Figures.The study focused on the mechanoresponse of Notch and in turn, that of angiogenesis. We hypothesized that this response could be explained through Notch interactions with mechano-sensitive YAP/TAZ. The modeled implementation was used to also investigate and suggest avenues through which to steer angiogenesis; by cytoskeletal manipulations and heterogeneous stiffness patterns.DOI: https://doi.org/10.1038/s41540-024-00444-3

本数据集关联论文《YAP/TAZ驱动计算机模拟中Notch与血管生成的机械调控》（YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico），内含用于运行所有模拟的MATLAB代码、拟合算法，以及用于生成全部图表的代码。该项研究聚焦于Notch的机械响应，以及由此介导的血管生成响应。我们提出假说：该响应可通过Notch与机械敏感YAP/TAZ的相互作用得到解释。本建模实现还被用于探究并提出调控血管生成的可行路径：通过细胞骨架操控与异质刚度模式实现。DOI: https://doi.org/10.1038/s41540-024-00444-3