Table_1_Elevated TyG index associated with increased prevalence of gallstones in a United States cross-sectional study.docx

ObjectiveThis study aimed to investigate the correlation between the triglyceride-glucose (TyG) index and the incidence of cholelithiasis.Research approachIn this investigation, a cross-sectional analysis was undertaken utilizing data from the US National Health and Nutrition Examination Survey (NHANES) spanning the years 2017 to 2020. The TyG index served as an independent predictor, while gallstone prevalence was considered the dependent variable of interest. We employed a multivariate logistic regression model to evaluate the interplay between these independent and dependent variables. To assess the presence of potential non-linear associations, sensitivity analysis was executed, utilizing inverse probability weighted validation, smooth curve fitting, and threshold effect analysis. In cases where non-linear relationships were observed, likelihood ratios were utilized to pinpoint potential inflection points. Ultimately, subgroup analyses were conducted to identify specific populations demonstrating heightened susceptibility to gallstone prevalence.ResultsEncompassing 838 patients who self-reported gallstones, a total of 7,794 participants were included in the analytical cohort. A statistically significant disparity in the TyG index was observed when all individuals were categorized into gallstone patients and non-patients (p

研究目的本研究旨在探究甘油三酯-葡萄糖指数（TyG指数）与胆结石发病率之间的相关性。研究方法在本项研究中，我们进行了一项横断面分析，利用2017年至2020年间美国国家健康与营养调查（NHANES）的数据。TyG指数作为独立预测指标，而胆结石的患病率被视为感兴趣的依赖变量。我们采用多变量逻辑回归模型来评估这些独立变量与依赖变量之间的相互作用。为了评估潜在的非线性关联，执行了敏感性分析，包括逆概率加权验证、平滑曲线拟合和阈值效应分析。在观察到非线性关系的情况下，利用似然比来定位潜在的拐点。最终，进行了亚组分析，以识别对胆结石患病率具有较高易感性的特定人群。研究结果涵盖了838名自报患有胆结石的患者，总共有7,794名参与者纳入分析队列。当所有个体被分为胆结石患者和非患者时，TyG指数存在显著的差异（p