NIH funded studies of pediatric

We formatted and analyzed all NIH funded registered studies of pediatric patients. We applied standardization and normalization methods using Elsevier’s Merged Medical Taxonomy terms and the corresponding ICD 10 codes, EMBASE taxonomy and natural language processing methods. We performed systemic appraisal of completed studies according to treatment allocation, masking of treatment status, early termination, and exclusion enrolled subjects from the analyses. We calculated treatment effect for all posted hypotheses and provided the interpretation of treatment effects according to statistical significance, direction, and magnitude of benefits and harms.