Oblate ellipsoidal tumors have a similar distribution of orientations regardless of viewing direction.

a. The relationship between tumor rotation angle, , and projected aspect ratio, , as an oblate ellipsoid with maximum aspect ratio of 3 ( = 3) is rotated about its () axis. b. The tumor rotation angle was calculated from the projected aspect ratio (part a) for tumors grown in 1% agarose for 30 days. Top image: observation perpendicular to the plane of the cell-culture well, Bottom image: side view perpendicular to a physical cross-section of the gel made with a scalpel blade (out-of-focus cut marks are visible in the gel) Scale bars are 200 µm.