Dynamic analysis of m6A methylation spectroscopy during progression and reversal of hepatic fibrosis

We constructed a model of progression and reversal of hepatic fibrosis by intraperitoneal injection of carbon tetrachloride (CCl4). Dynamic m6A methylation was evaluated using MeRIP-Seq technique in the progression and reversal of hepatic fibrosis, and of the normal age-matched control groups. Genes with differentially m6A methylated sites and expression were analyzed to reveal the over-represented gene ontologies and pathways at different stages Dynamic analysis of differential methylation and expression of genes during the first, third and sixth weeks of progression of liver fibrosis and the first and second weeks of reversal, to explore the dynamic changes of methylation during hepatic fibrosis contributor: National Natural Science Foundation of China (81608129/ 81772941) contributor: Cloudseq