Therapeutic effects of EGCG in experimentally induced ulcerative colitis in rats via affecting inflammation and apoptosis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that
affects the colon. Epigallocatechin gallate (EGCG), a compound found in
green tea with antioxidant and anti-inflammatory properties. We aimed to
investigate the impact of EGCG on inflammation and apoptotic pathways in
UC rats. The study involved inducing UC in rats by administering acetic
acid. The UC rats were then treated with EGCG. Colon samples were
collected, measured then used to evaluate gene and protein expression of
various factors, including NF-κB, TNF-α, SphK, MIP-1α, BCL2, and BAX, as
well as the activities of caspase-3/8/9.