Therapeutic effects of EGCG in experimentally induced ulcerative colitis in rats via affecting inflammation and apoptosis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects the colon. Epigallocatechin gallate (EGCG), a compound found in green tea with antioxidant and anti-inflammatory properties. We aimed to investigate the impact of EGCG on inflammation and apoptotic pathways in UC rats. The study involved inducing UC in rats by administering acetic acid. The UC rats were then treated with EGCG. Colon samples were collected, measured then used to evaluate gene and protein expression of various factors, including NF-κB, TNF-α, SphK, MIP-1α, BCL2, and BAX, as well as the activities of caspase-3/8/9.