The focus of this study was to identify changes in host gene expression induced by the transcription-dependent function of the viral AC2 protein, and induced by the interaction of AC2/C2 with SnRK1.2
Protein lysates of Xrn1 knock out (ko) A549 cells infected with WT PR8 or PR8-PA(∆X), or mock infected, were probed with antibodies against PR8 PA or beta-tubulin as a loading control.
mRNA expression profiles were compared between wild-type and Lba1 KO BMDC infected with Sendai virus. WT and LBA1 KO BMDC were diferentiated and infected with Sendai virus for 6 hours. Total RNA was