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Distinct immune escape mechanisms identified in intrahepatic cholangiocarcinoma by immune classification

ChEBI2019-12-28 更新2026-07-12 收录

肝内胆管癌免疫微环境

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数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-6389 数据链接链接失效反馈

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Distinct immune escape mechanisms identified in intrahepatic cholangiocarcinoma by immune classification

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创建时间：

2019-12-28

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PD-L1调控

To identify the potential signaling pathway involved in DENR KO cells upon PD-L1 production, we harvested IFNγ-treated control and DENR KO cells for RNA-seq. Bioinformatic analysis of the RNA-seq data

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Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity

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表观遗传调控

Isocitrate Dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved

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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma [ChIP-seq/CUT&RUN]

癌症转录调控

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In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of

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Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Synthesis [scRNAseq]

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免疫治疗联合策略

Therapeutic resistance to immune checkpoint blockade remains a prevalent obstacle across many cancer types, and an improved mechanistic understanding of this process could lead to effective combinatio

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Human Tumour Immune Evasion via TGF-β Blocks NK Cell Activation but Not Survival Allowing Therapeutic Restoration of Anti-Tumour Activity

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细胞功能调控

Immune evasion is now recognized as a key feature of cancer progression. In animal models, the activity of cytotoxic lymphocytes is suppressed in the tumour microenvironment by the immunosuppressive c

Figshare2016-01-18 更新40

Distinct immune escape mechanisms identified in intrahepatic cholangiocarcinoma by immune classification

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