File S1 - Assessment of Metabolomic and Proteomic Biomarkers in Detection and Prognosis of Progression of Renal Function in Chronic Kidney Disease

Supporting tables. Table S1, List of significantly identified biomarkers between “Mild CKD vs. Advanced CKD” at baseline. 46 peptides, 17 plasma metabolites and 13 urinary metabolites derived from the training set of mild and advanced CKD at baseline. The statistical and correlation analysis of each biomarker with the eGFR were performed at baseline. In the table, the biomarker marker ID, name, type, source, the Spearman's rank correlation coefficient and its p-values, the p-values from the statistical analysis (Benjamini Hochberg), the comparison with biomarkers identified in previous CKD studies were provided. In the “comparison with CKD studies” column, x indicates that the biomarker was previously identified. Table S2, Raw data of identified peptides at baseline. The raw data of all 46 peptides were provided at baseline for the 49 patients used in the study. Each column represents a patient and the patient ID goes from 1 to 49. Table S3, Raw data of identified metabolites at baseline. The raw data of all 30 metabolites (17 in the plasma and 13 in the urine) were provided at baseline for the 49 patients used in the study. Each column represents a patient and the patient ID goes from 1 to 49. (XLS)