B-Raf Kinase V600E mutant in complex with a diarylthiazole B-Raf Inhibitor
收藏Protein Data Bank Japan2023-12-20 更新2026-03-21 收录
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https://pdbj.org/mine/summary/4cqe
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B-Raf Kinase V600E mutant in complex with a diarylthiazole B-Raf Inhibitor Descriptor: N-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide, SLC45A3-BRAF FUSION PROTEIN Authors: Casale, E, Fasolini, M, Pulici, M, Traquandi, G, Marchionni, C, Modugno, M, Lupi, R, Amboldi, N, Colombo, N, Corti, L, Gasparri, F, Pastori, W, Scolaro, A, Donati, D, Felder, E, Galvani, A, Isacchi, A, Pesenti, E, Ciomei, M. Deposit date: 2014-02-14 Release date: 2014-12-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Optimization of Diarylthiazole B-Raf Inhibitors: Identification of a Compound Endowed with High Oral Antitumor Activity, Mitigated Herg Inhibition, and Low Paradoxical Effect. Chemmedchem, 10, 2015
创建时间：
2014-02-14
