LCCC 1108 (UNCseqTM)

The primary objective of this specimen correlative study was two-fold: to provide a mechanism for the association of known molecular alterations with clinical outcomes, and to provide rapid genetic profiling of alterations with known clinical utility using tumor and germline specimens to support treatment decisions.]]>
Inclusion Criteria: 1.Current or prospective cancer patients; current cancer patients must have histologically or cytologically confirmed diagnosis of cancer 2.Tumor tissue available and suitable for molecular analyses from at least one of the following sources: Tissue previously stored in UNC's Tissue Procurement Facility (TPF) Tissue previous stored at an institution other than UNC-CH, provided investigators can determine that the tumors were sampled and stored under appropriate conditions for inclusion in the study Patient undergoing tissue collection as per clinical standard of care and willing to allow specimens from surplus tissue to be diverted for research purposes Patient undergoing tissue collection as per clinical standard of care and willing to have additional specimens taken for research Patient willing to undergo biopsy for purpose of research only Exclusion Criteria: Any condition that would make participation in the protocol unreasonably hazardous for the patient in the opinion of the treating physician Affected by dementia, altered mental status, or any psychiatric or co-morbid condition that would prohibit the understanding or rendering of informed consent ]]>
September 2011: study start June 2018: study completion ]]>