Divergent clonal selection dominates medulloblastoma at recurrence. Mus musculus

The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon driven, functional genomic mouse model of medulloblastoma with ‘humanized’in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched diagnostic samples.