Poecilia picta female genome assembly files

Sex chromosome dosage compensation is a model to understand the coordinated evolution of transcription, however, the advanced age of the sex chromosomes in model systems makes it difficult to study how the complex regulatory mechanisms underlying chromosome-wide dosage compensation can evolve. The sex chromosomes of Poecilia picta have undergone recent and rapid divergence, resulting in widespread gene loss on the male Y, coupled with complete X Chromosome dosage compensation, the first case reported in a fish. The recent de novo origin of dosage compensation presents a unique opportunity to understand the genetic and evolutionary basis of coordinated chromosomal gene regulation. By combining a new chromosome-level assembly of P. picta with whole-genome bisulfite sequencing and RNA-seq data, we determine that the Yin Yang 1 (YY1) DNA-binding motif is associated with male-specific hypomethylated regions on the X, but not the autosomes. These YY1 motifs are the result of a recent and rapi..., , , # Poecilia picta female genome assembly files

[https://doi.org/10.5061/dryad.5qfttdzcf](https://doi.org/10.5061/dryad.5qfttdzcf)

**Poecilia_picta_female_genome.fasta**
Genome assembly .fasta file for the female *Poecilia picta* genome assembly. The assembled genome containing 23 chromosomes, unassembled scaffolds, and the mitochondrial genome. Chromosomes are named based on synteny with the *Poecilia reticulata* female genome assembly.

**Poecilia_picta_female_genome_annotation.gff3**
The accompanying gene annotation file for the Poecilia_picta_female_genome in .gff format. Annotations were generated by the Dovetail genomics annotation pipeline aided by RNA-seq data from muscle, head, liver, testis, and ovary tissue.

NOTE: a previous version of this file ending in .gff contained multiple annotation errors. These errors have been corrected in the updated .gff3 annotation file.

**PO1787_Poecilia_picta.transcript.fasta**
Gene CDS sequences in .fasta format.

**PO1787_Poecilia_picta.pro...