Transcriptional changes induced by I-BET151-treated cells mimic those induced by differentiating cells.

(A) Plot showing median RPKM for all genes within the indicated functional groups at each time point after induction with I-BET151 (solid lines). For comparison, median expression values for all genes within the indicated functional groups were derived from data generated in [12] and plotted as dashed lines. Colors between solid and dashed lines are matched for each functional group. All functional groups with a GSEA FDR of 70% of genes were up-regulated or down-regulated at 48 h of I-BET151 treatment are plotted. (B) Examples of 3 functional groups that do not match our criteria of a GSEA FDR of 70% of genes were up-regulated or down-regulated at 48 h. mit F1, F1 ATPase, mit MCP, mitochondrial carrier proteins, mit imp, import of mitochondrial proteins. Numerical data for Fig 2 is in S2 Data.