<b>MMP13-</b><b>Mediated Fibronectin Degradation Facilitates Coronavirus Attachment to Integrin αvβ3 and Enhances Viral Invasion</b>

This study uncovers a conserved coronavirus strategy in which PEDV infection up-regulates host MMP13 via the IL-1β/JNK pathway. Elevated MMP13 degrades extracellular fibronectin, removing its competitive blockade of PEDV spike–integrin αvβ3 binding and thereby accelerating viral entry. The same MMP13–fibronectin–αvβ3 axis is exploited by SARS-CoV-2 and porcine deltacoronavirus, revealing a potential pan-coronavirus therapeutic target.<br><br>Data citation requirement<br>This dataset is released under the Creative Commons Attribution 4.0 International License (CC BY 4.0).<br>If you use any file or derived data, you must cite the dataset: "MMP13-Mediated Fibronectin Degradation Facilitates Coronavirus Attachment to Integrin αvβ3 and Enhances Viral Invasion" Figshare. DOI: 10.6084/m9.figshare.29881502<br>