The gene regulation of miR-10a* in lung cancer (microRNA). Homo sapiens

This study aimed to investigate the metastasis-related prognostic gene signature in lung cancer. We started from the genowide miRNAs profiling of 16 lung adenocarcinoma cells. We identified that miR-10a* is an invasion-based prognostic gene in lung adenocarcinoma. Besides, we used expression beadsarray to identify the global gene alterations in HOP-62 cells after ectopic introducing miR-10a* and ectopic expressing HDAC5 genes. Overall design: All 16 lung adenocarcinoma cells were parental. Ectopic introducing miR-10* mimics and expressing HDAC5 in HOP-62 cells.