Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [RNA-seq]. Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [RNA-seq]

EZH2 induces active transcription of the AR gene, thereby increasing AR level and promoting AR signaling. Importantly, EZH2-mediated activation of AR requires EZH2 protein occupancy at the AR gene promoter, but is independent of PRC2 as well as its histone methyltransferase activity Overall design: RNA-seq examination of combinatorial effects of ENZ+EPZ in prostate cancer cells signaling pathway