Coding dataset and digitised release curves for a review of time-programmable hydrogels for spinal cord injury

Coding dataset and digitised release curves accompanying a review oftime-programmable hydrogels for spinal cord injury. This deposit contains everything needed to recompute every quantitative claim inthe review. Supplementary_Table_S1_coding.xlsx codes all 57 included primarystudies on three axes: the chemical cue that orders the later release event, thetemporal level of the design (one cue; an ordered pair; a chain crossing three ormore pathological stages), and the pathological stage each system targets.Supplementary_Table_S2_window_assignment.xlsx records the target window assignedto each of the fourteen payloads and the basis for that assignment.Supplementary_Table_S3_sensitivity.xlsx gives the temporal matching index forthe seven systems with published release data under three window-boundaryscenarios. Supplementary_Table_S4_digitised.xlsx holds the release values readpoint by point from the published curves (fourteen payloads, 153 points). tmi.py is a short reference implementation of the temporal matching index:TMI = 1 - |ln(t_half / t_mid)| / ln(W), where t_mid is the geometric midpoint ofthe target window and W its width as a ratio. Running "python tmi.py demo"reproduces Table 2 of the review from the digitised curves, 14 of 14 payloadscores, and prints each computed value next to the published one. Two limits are stated in the README and apply to any reuse. The half-releasetimes are in vitro quantities, measured in buffer or enzyme solution; in tissuethe same material will usually release faster, so the index scores the timing adesign intends rather than the timing a lesion receives. And the window assignedto a payload is a judgement, documented payload by payload; it is the dominantsensitivity of the index, moving the DSDH and RA@Lip system scores from 0.21 and0.06 to about 0.55 and 0.54 if the three immune payloads are assigned to theacute rather than the subacute window. Licence: CC BY 4.0. Please cite the companion manuscript and this deposit.README.md explains the field dictionary and the limits that apply to reuse;MANIFEST.tsv lists file sizes and MD5 checksums so that a download can beverified after transfer.