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Raw data from sodium current recordings obtained from untagged human and mouse sodium channels (Nav1.5) expressed in HEK293 cells.

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f1000.figshare.com2023-05-31 更新2025-03-21 收录
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https://f1000.figshare.com/articles/dataset/Raw_data_from_sodium_current_recordings_obtained_from_untagged_human_and_mouse_sodium_channels_Nav1_5_expressed_in_HEK293_cells_/155795/1
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For each channel type the cells are numbered starting from 1. For the sake of similar conditions (cells from the same passage, recordings on the same day, same solution aliquots), new cells have been recorded for the tag study. There are two sheets per channel type: one with data from the current voltage (I/V) activation, together with the steady-state inactivation (SSI) protocol; and a second one with data obtained with the onset of slow inactivation (OSI) and the recovery from inactivation (RFI) protocol. For some cells, only some of the protocols have been applied (thus non-continuous cell numbering in some OSI/RFI sheets). All measured voltages are given in mV; cell capacitance was measured in pF. Note that the cells transfected with untagged hNav1.5 used for comparison with mNav1.5 are not the same as in the study with different tags. See Figure 2 and 4 for information about the applied protocols.

针对每一种信道类型,细胞编号从1开始。为了确保相似条件(同一途径的细胞、同一天的记录、相同的溶液等分),针对标签研究,新细胞已被记录。每个信道类型有两张表格:一张包含当前电压(I/V)激活数据以及稳态失活(SSI)协议数据;另一张则包含使用慢失活起始(OSI)和失活恢复(RFI)协议获得的数据。对于某些细胞,仅应用了部分协议(因此某些OSI/RFI表格中存在非连续的细胞编号)。所有测量的电压均以毫伏(mV)为单位;细胞电容的测量单位为皮法拉(pF)。请注意,用于与mNav1.5进行比较的、未标记的hNav1.5转染的细胞与使用不同标签的研究中的细胞不同。请参阅图2和图4以获取关于应用协议的信息。
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