PAUP analysis of SGA events distribution on lineages of within-individual phylogenies suggests that the greatest number of SGA events occurred on outlier minority of lineages that evolved during off-NSAID periods.

Two violin plots show the distribution of lineage lengths (estimated number of SGA events) that evolved during off-NSAID (white) and on-NSAID (grey) periods within an individual phylogeny (solid line across the violin denotes the median). The volumes of a pair of violin plots are scaled relative to the number of data points the pair contains. Scatter plots show the raw data underlying the violin plots and illustrate the outliers. The majority of individual phylogenies (a, b, d, e, f, g, h, i, j, k) show an off-NSAID lineage containing the maximum number of SGA events.