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Cognitive behavioral therapy has a positive effect on improving the emotional issues of patients with generalized anxiety disorder. However, the role of group cognitive behavioral therapy in alleviating symptoms and enhancing quality of life still requires further verification. This study explores the improvement effect of high-frequency short-term group cognitive behavioral therapy combined with selective serotonin reuptake inhibitor (SSRI) medication on the clinical symptoms and quality of life of patients with generalized anxiety, aiming to optimize clinical treatment plans. Using a randomized controlled trial design, 85 GAD patients were divided into an intervention group (receiving short-term structured group cognitive-behavioral therapy along with standard medication) and a control group (receiving only standard medication). The Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Short Form Health Survey (SF-36) were assessed before treatment and at one week and four weeks post-treatment.