Gene expression profile at single cell level of retinal cells of mitochondrial ND6 13997 G>A mutant mouse

LHON is a paraLeber hereditary optic neuropathy (LHON) is a paradigm for mitochondrial retinopathy due to mitochondrial DNA (mtDNA) mutations. However, the mechanism underlying retinal cell-specific effects of LHON-linked mtDNA mutations remains poorly understood and there has been no effective treatment or cure for this disorder. We use scRNA-seq to study the retinal cell-specific deficiencies caused by LHON-linked ND6P25L mutation. Retinas from Wildtype and ND6 mutant mice of 7 month old was dissected and analyzed by scRNA-seq