Crystal structure of mouse PRMT6 in complex with inhibitor EML980
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Crystal structure of mouse PRMT6 in complex with inhibitor EML980 Descriptor: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate Authors: Bonnefond, L, Cavarelli, J. Deposit date: 2021-07-06 Release date: 2022-05-11 Last modified: 2025-12-10 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65, 2022
创建时间：
2021-07-06
