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TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE172119
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To elucidate the molecular mechanisms by which 14-3-3ε and PGRN regulates macrophage plasticity, we performed unbiased RNA-seq on BMDMs isolated from WT, PGRN-/- and 14-3-3ε-/- mice stimulated with pro-inflammatory LPS/IFNγ or anti-inflammatory IL-4. mRNA frofiles of WT, PGRN-/- and 14-3-3e-/- BMDMs polarized to M1 or M2 macrophages
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2022-04-14
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