ChIP-seq BigWig signal tracks for genome-wide chromatin profiling in CD34+ PB-HSPCs and

These bigWig files contain normalized ChIP-seq signal tracks generated from CD34+ PB-HSPCs and in vitro differentiated megakaryocytes and monocytes. The data represent genome-wide binding profiles of H3K27ac, H3K27me3, and H3K4me3 and were used to identify regulatory regions and chromatin features associated with gene regulation in myeloid leukemia associated with Down syndrome.
The bigWig format allows efficient visualization of signal intensity across the genome in genome browsers such as IGV or UCSC. These files can be used for data exploration, figure reproduction, and re-analysis of chromatin occupancy at promoters, enhancers, and other regulatory elements. Data is in hg19.
As part of DLK1 is a GATA1s-Driven Dependency and Therapeutic Target in Down Syndrome-Associated Myeloid Leukemia
Running title: Targeting DLK1 in ML-DS