Twelve-Step Asymmetric Synthesis of (−)-Nodulisporic Acid C
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https://figshare.com/articles/dataset/Twelve-Step_Asymmetric_Synthesis_of_-Nodulisporic_Acid_C/7148846
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A short, enantioselective synthesis of (−)-nodulisporic acid C is described. The route features two highly diastereoselective polycyclizations en route to the terpenoid core and the indenopyran fragment and a highly convergent assembly of a challenging indole moiety. Application of this chemistry allows for a 12-step synthesis of the target indoloterpenoid from commercially available material.
创建时间:
2018-10-01



