Reprogramming fate of central memory CD8+T cells by targetig the transcriptional coregulator Tle3 [scRNA-seq]

The goal of this study is to determine if central memory (Tcm) and effector memory (Tem) CD8 T cells can be reprogrammed to change their fate. We demonstrate that genetic ablation of Tle3 can promote generation of Tcm cells at the expense of Tem cells, and this can occur during the effector phase of the immune response. Single cell RNAseq analysis of WT or Tle3-deficient antigen-specific memory CD8 T cells isolated on day 30 after infection with LCMV-Armstrong.