Short chain fatty acids (SCFAs) are small metabolites that are produced through the activity of microbes and have important roles in human physiology. These metabolites have varied mechanisms in inter

NIAID Data Ecosystem40

chromatin Remodeling in Patient-Derived Colorectal Cancer Models

结直肠癌表观遗传学

染色质可及性分析

Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare the epigenomes of different patient-derived models of c

NIAID Data Ecosystem40

Comprehensive identification and characterization of the binding sites in HCT116 cells

ChIP-seq结合位点鉴定

结直肠癌表观遗传学

Comprehensive identification and characterization of the binding sites of HCT116 cells. We used ChIP-Seq method, in which next gene sequencing technology and chromatin-immunopr

NIAID Data Ecosystem50

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription. ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

结直肠癌表观遗传学

内源性逆转录病毒

Purpose: The transposable elements (TEs) through evolutionary exaptation have become an integral part of human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While

NIAID Data Ecosystem40

Cell-of-origin epigenetic signatures are maintained during colorectal carcinogenesis

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