Butera1999_Bursting_Pacemaker_Neuron_Model_1

This is the model without the slow potassium current, model 1, described in the article:
Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons.

Butera RJ Jr, Rinzel J, Smith JC. J Neurophysiol.
1999 Jul;82(1):382-97. Pubmed ID: 10400966
, full text
at the Journal of Neurophysiology
.
Abstract:

A network of oscillatory bursting neurons with excitatory coupling is hypothesized to define the primary kernel for respiratory rhythm generation in the pre-Bötzinger complex (pre-BötC) in mammals. Two minimal models of these neurons are proposed. In model 1, bursting arises via fast activation and slow inactivation of a persistent Na+ current INaP-h. In model 2, bursting arises via a fast-activating persistent Na+ current INaP and slow activation of a K+ current IKS. In both models, action potentials are generated via fast Na+ and K+ currents. The two models have few differences in parameters to facilitate a rigorous comparison of the two different burst-generating mechanisms. Both models are consistent with many of the dynamic features of electrophysiological recordings from pre-BötC oscillatory bursting neurons in vitro, including voltage-dependent activity modes (silence, bursting, and beating), a voltage-dependent burst frequency that can vary from 0.05 to > 1 Hz, and a decaying spike frequency during bursting. These results are robust and persist across a wide range of parameter values for both models. However, the dynamics of model 1 are more consistent with experimental data in that the burst duration decreases as the baseline membrane potential is depolarized and the model has a relatively flat membrane potential trajectory during the interburst interval. We propose several experimental tests to demonstrate the validity of either model and to differentiate between the two mechanisms.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Butera, Rinzel, Smith, 1999 version 05

The original CellML model was created and curated by:
Catherine May Lloyd

c.lloyd(at)auckland.ac.nz
The University of Auckland, Bioengineering Institute
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