Effects of NVP-BEZ235 on proliferation of normal and neoplastic cells.*

*Proliferation was determined by measurement of 3H-thymidine uptake as described in the text.**Diagnoses were established according to published criteria (12,13).***Normal/reactive BM cells were obtained from patients with NHL without BM involvement.Abbreviations: f, female; m, male; yrs, years; BM, bone marrow; MNC, mononuclear cells; ISM, indolent systemic mastocytosis; SSM, smoldering systemic mastocytosis; NHL, Non Hodgkin's Lymphoma; MCL, mast cell leukemia; CML, chronic myeloid leukemia; n.d., not determined; n.a., not applicable.